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MyWikiBiz, Author Your Legacy — Friday November 29, 2024
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== About GENEWIZ ==
[http://www.genewiz.com GENEWIZ]is a contract research organization specializing in [http://www.genewiz.com/public/DNA-sequencing-services.aspx DNA sequencing], [http://www.genewiz.com/public/gene-synthesis.aspx gene synthesis], molecular biology, and genomic services. Its customers include individual researchers and institutional partners, both national and international. Founded in 1999 by former biomedical researchers, GENEWIZ well understands what researchers need in order to facilitate their research progress. Since then, GENEWIZ has helped thousands of scientists in pharmaceutical, biotechnology, academic, and government sectors to meet their research goals.
GENEWIZ is an operational excellence company with a customer-driven strategy. It has become the leader in DNA sequencing and molecular biology services by providing the best combination of value - fast turnaround time, specialized expertise, competitive prices, and friendly customer support.
== About [http://www.genewiz.com/public/DNA-sequencing-services.aspx GENEWIZ DNA Sequencing Services] ==
DNA sequencing should be the easiest part of research project! As former researchers [http://www.genewiz.com GENEWIZ] understands the importance of fast, accurate results, and the need for a responsive sequencing partner.
The nation’s top academic, biotech, and pharmaceutical institutions trust GENEWIZ’ award-winning [http://www.genewiz.com/public/DNA-sequencing-services.aspx DNA Sequencing Services]. These are the service options:
• Plasmid Sequencing
• Purified PCR Product Sequencing
• PCR Clean Up & Sequencing
• Difficult Template Sequencing
• Primer Walking
• Shotgun Sequencing
• TA Cloning & Sequencing
• Direct Bacterial Colony Sequencing
• Direct Glycerol Stock Sequencing
• Direct Phage With Circular Genome Sequencing
• BAC End Sequencing
• GLP DNA Sequencing
== About [http://www.genewiz.com/public/gene-synthesis.aspx GENEWIZ Gene Synthesis Services] ==
Gene synthesis is an excellent alternative to molecular cloning for custom construct production. Other important applications for de novo gene synthesis include the development of DNA vaccines, vectors for gene therapy, and gene libraries for protein engineering and directed molecular evolution.
A'''LGORITHMS FOR GENE SYNTHESIS''': DNA sequences which contain codon frequencies that differ significantly from the vectors usage bias will reduce translation efficiency of the protein and negatively impact expression levels. Thus, optimizing codon choice in the design of a synthetic gene is a critical factor in successful protein expression.
''Oligo Design Algorithms'':
• Minimize synthesis and assembly errors.
• Reduce variance in oligo melting temperature
• Result: Reliably designed oligos can be synthesized and assembled into the desired target gene
''Codon Optimization Algorithms'':
• Match codon frequency in the desired sequence with the usage bias of the vector
• Optimize genes to prevent transcribed mRNAs from forming pesky secondary structures
• Satisfy your specific requirements for restriction sites.
• Minimize occurrences of undesirable motifs and maximize occurrences of desirable motifs (For example: CpG motifs for immuno-modulation, cryptic splice sites for splicing).
• Consider essential parameters including GC content, repeat sequences, mRNA instability motifs, inhibition sites, premature PolyA sites and so on
Result: Enhance target protein expression in a host cell
== Why Gene Synthesis is better than the traditional cloning? ==
Why are scientists still frustrated with the slow pace of your traditional cloning project? It is time to try gene synthesis.
You might have gotten used to the molecular cloning and subcloning without thinking of alternatives.
Compare traditional cloning with GENEWIZ's Gene Synthesis Service, you can see the reasons why gene synthesis is a better alternative:
[[Image:Example.jpg]]
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