Section Contents:<a name="top"></a>
- In theory, and based on limited animal study, horse chestnut seed extract may have an additive effect when taken with other herbs or supplements that may lower blood sugar.<a href="#hdng0">(More...)</a>
- Purpose The objectives of this study are to evaluate the effectiveness of escin (as horse chestnut seed extract) for arm lymphedema in women following treatment for breast cancer, to evaluate the accuracy and sensitivity of bioelectric impedance as a measurement of lymphedema of the arm, and to validate the proposed arm lymphedema quality-of-life questionnaire.<a href="#hdng1">(More...)</a>
<a name="hdng0"></a>
In theory, and based on limited animal study, horse chestnut seed extract may have an additive effect when taken with other herbs or supplements that may lower blood sugar. <a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> In theory, and based on limited animal study, horse chestnut seed extract (HCSE) may have an additive effect when taken with drugs that cause hypoglycemia (low blood sugar levels).<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a>
Consult a healthcare provider immediately if you experience side effects. Horse chestnut seed extract (HCSE) may cause an allergic reaction in patients with known allergy to horse chestnuts, esculin, or any of its ingredients (flavonoids, biosides, trisides of quertins, and oligosacharides including 1-ketose and 2-ketose).<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Horse chestnut seed extract (HCSE) standardized to escin content should not contain significant levels of esculin and should not have the same risks.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Horse chestnut seed extract (HCSE) is widely used in Europe for chronic venous insufficiency (CVI), a syndrome that may include leg swelling, varicose veins, leg pain, itching, and skin ulcers.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Bassler D, Okpanyi S, Schrodter A, et al. Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a>
Several studies report the development of pseudolupus (a syndrome characterized by recurrent fever, muscle pain, and lung and heart muscle inflammation) in patients taking Venocuran or Venopyronum, which contains phenopyrazone, horse chestnut extract, and cardiac glycosides. Because these are combination products, these effects may not be accounted for by horse chestnut alone.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Rehn D, Unkauf M, Klein P, et al. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin).<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Deaths have been reported in children who ate raw horse chestnut seeds or tea made from horse chestnut leaves and twigs.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Unprocessed horse chestnut seeds have been associated with significant toxicity and death. Symptoms associated with horse chestnut poisoning may include vomiting, diarrhea, headache, confusion, weakness, muscle twitching, poor coordination, coma, or paralysis.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Horse chestnut leaf has been associated with liver inflammation (hepatitis) after injection into muscle.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a>
Allergic skin rashes (contact dermatitis) have been reported after use of a skin cream containing horse chestnut seed extract.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> There is not enough scientific research to recommend the safe use of horse chestnut or HCSE during pregnancy and breastfeeding.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Aflatoxins, considered to be cancer-causing agents, have been identified in commercial skin products containing horse chestnut, but not in HCSE.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> A gel preparation of horse chestnut containing 2% escin (applied to the skin 3-4 times daily) has been studied for bruising, without clear benefits.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> In theory, horse chestnut may interact with neurologic herbs and supplements.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> There is not enough scientific evidence to recommend use of horse chestnut in children.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a> Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children.<a href="
http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-horsechestnut.html" TARGET="_blank"
[1]</a>
Horse chestnut seed extract has been used to treat chronic venous insufficiency (a condition in which the veins in the legs do not efficiently return blood to the heart). This condition is associated with varicose veins, pain, ankle swelling, feelings of heaviness, itching, and nighttime leg cramping.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> Small studies have found that horse chestnut seed extract is beneficial in treating chronic venous insufficiency and is as effective as wearing compression stockings.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a>
Horse chestnut seed extract standardized to contain 16 to 20 percent aescin (escin), the active ingredient, is the most commonly used form.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> When properly processed, horse chestnut seed extract contains little or no esculin and is considered generally safe.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> Raw horse chestnut seeds, leaves, bark, and flowers contain esculin, which is poisonous.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> Includes flowers, leaves, bark, fruit, seeds, stems, and roots. or dietary supplement A product that contains vitamins, minerals, herbs or other botanicals, amino acids, enzymes, and/or other ingredients intended to supplement the diet. The U.S. Food and Drug Administration has special labeling requirements for dietary supplements and treats them as foods, not drugs. you are using, including horse chestnut. This helps to ensure safe and coordinated care.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> For centuries, horse chestnut seeds, leaves, bark, and flowers have been used for a variety of conditions and diseases.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> There is not enough scientific evidence to support the use of horse chestnut seed, leaf, or bark for any other conditions.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a>
Although horse chestnut is sometimes called buckeye, it should not be confused with the Ohio or California buckeye trees, which are related but not the same species.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a> Horse chestnut trees are native to the Balkan Peninsula (for example, Greece and Bulgaria), but grow throughout the northern hemisphere.<a href="
http://nccam.nih.gov/health/horsechestnut/" TARGET="_blank"
[2]</a>
The Common Horse Chestnut, which lines the boulevards of Paris, is a native of Greece and Bulgaria. It was brought to this country at an early date and has been extensively used as a shade tree and street tree. It has a very symmetrical shape and its flowers, which are white tinged with red, grow in clusters from 8 to 12 inches tall. Its leaf has from 5 to 7 leaflets and the fruit is similar to that of the Ohio Buckeye.<a href="
http://www.newton.dep.anl.gov/natbltn/200-299/nb266.htm" TARGET="_blank"
[3]</a>
<a href="#top"><img alt="Back to Top" title="Back to Top" src="
" style="border: 0px solid ; width: 72px; height: 14px;"></a>
<a name="hdng1"></a>
Purpose The objectives of this study are to evaluate the effectiveness of escin (as horse chestnut seed extract) for arm lymphedema in women following treatment for breast cancer, to evaluate the accuracy and sensitivity of bioelectric impedance as a measurement of lymphedema of the arm, and to validate the proposed arm lymphedema quality-of-life questionnaire. <a href="
http://clinicaltrials.gov/ct2/show/NCT00213928?cond="Lymphedema"&rank=20" TARGET="_blank"
[4]</a>
<a href="#top"><img alt="Back to Top" title="Back to Top" src="
" style="border: 0px solid ; width: 72px; height: 14px;"></a>
" width="800" height="45" align="middle">
" width="800" height="45">
" alt="Pertinent Info, most relevant to your research."></a>
" title="Submit advanced request" align="center" height="21" type="image" width="77"></form>
