Directory:LifeTein.com
Name: LifeTein.com
Address: 150 Maple AvenueCity: South Plainfield
State: New Jersey
Zip: 07080
Country: USA
Phone: 1-732-312-5852
Email: [mailto:info@lifetein.com info@lifetein.com]
Web: http://www.lifetein.com
Contact: Phil Moore
Title: Director of Business Development
About LifeTein
LifeTein, the peptide synthesis company, has developed its proprietary PeptideSyn Peptide Synthesis Technology (http://www.lifetein.com/peptide_tech.html), which was developed from our campus core facility. This technology provides continuous flow of peptide synthesis platform and renders competitive custom peptide synthesis price. Using the saved peptide production costs, we are able to serve the campus and now worldwide scientific community more cost-effectively. Thanks to the PeptideSyn Peptide Synthesis Technology using the Fmoc and Boc chemistry and a patented solid support resin, LifeTein offers high quality custom peptide synthesis services at very competitive peptide prices.
Try our custom peptide synthesis services (http://www.lifetein.com/peptide_synthesis_services.html) and listen to what our customers say about our custom peptide synthesis services:
Large capacities: capacity to produce 5,000 purified peptides monthly ranging from crude to highly pure and complex peptides.
Ensured quality: Peptide synthesis projects are carried out by Fmoc and Boc chemistry under the strictest quality control based on HPLC and by mass spectrometry. 95% of all projects are finalized in 2-3 weeks to guarantee the on time delivery.
Data protection: All sequences supplied to LifeTein are considered the confidential property of the customer. At the completion of the project all synthetic peptide meeting the purity criteria is sent to the customer.
Peptides - From Discovery to Therapeutics
Peptides are short polyers formed from the peptide bond linking, in a defined order, of α-amino acids. The major classes of peptides include ribosomal peptides, non-ribosomal peptides, peptones and peptide fragments. The hypothalamic peptide hormone gonadotropin-releasing hormone (GnRH) is an example of ribosomal peptides. The peptide is synthesized by translation of mRNA. GnRH is subjected to a regulatory proteolytic pathway to generate the mature form. Non-ribosomal peptides are usually produced by bacteria or fungi. Nonribosomal peptides often have a cyclic and/or branched structures. For example, Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group. Peptones are derived proteins, which may be produced by hydrolysis of a native protein with an acid or enzyme. Peptide fragments refer to fragments of proteins that are used to identify or quantify the source protein.
Peptides play an important role in molecular biology, biochemistry, immunology and medicine. Synthetic peptides have been widely used for structure-function studies of polypeptides. The processes involve initiation or inhibition through protein-protein interaction. Take a non-formyl peptide (HP-20) for example. The rapid intracellular calcium mobilization of HP-20 was measured for human neutrophils in order to explore its interaction with the formyl peptide receptor (FPR).
PeptideSyn Peptide Synthesis Technology
The conventional solid phase peptide synthesis (SPPS) typically uses long coupling time of up to one hour or more, extended deprotection times, multiple wash steps as well as Kaiser tests to insure complete acylations. This increases synthesis time especially when synthesizing the complex peptides such as beta-amyloid, which has high hydrophobicity of the C-terminal segment and subsequent on-resin aggregation. The rate of amino acid acylation is heavily dependent on the properties of the coupling. Therefore, the ability to assemble peptides faster with a reasonable quality is highly desirable.
LifeTein's PeptideSyn Peptide Synthesis Technology was developed from a campus core facility. It is a very practical platform for the synthesis of peptides for pharmaceutical companies, active pharmaceutical ingredient (API) purpose and university research laboratories. The PeptideSyn Peptide Synthesis Technology has been used for in-house testing of multiple selected biologically active peptides with a broad range of properties including long and short peptides, as well as peptides containing D-amino acids or pseudoproline dipeptides using various coupling reagents such as HBTU, HATU, HCTU, ByBroP, BOP, PyBOP and TBTU. The PeptideSyn Peptide Synthesis Technology allows us to have the flexibility to choose affordable, highly efficient coupling reagents for fast SPPS. One study using the PeptideSyn Peptide Synthesis Technology shows that the synthesis of the human beta-amyloid (1-C42) peptide (HDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH) using HCTU as activators renders a total synthesis time of 15 h with similar purity to the long synthesis. Wang-ChemMatrix, HMPB-ChemMatrix, and Wang-PSLL were compared for their efficiency on different synthesis.
Using appropriate coupling and deprotectant reagents linked to the correct resin, LifeTein's PeptideSyn Peptide Synthesis Technology provides our customers with reduced total peptide synthesis time and higher quality.
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