Feverfew - Get the Facts on Herbal Supplements

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  • Recently, feverfew has been used for migraine headaches and rheumatoid arthritis.<a href="#hdng0">(More...)</a>

  • Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups.<a href="#hdng1">(More...)</a>



<a name="hdng0"></a>Recently, feverfew has been used for migraine headaches and rheumatoid arthritis. <a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a> Standardized preparations could be used in future studies of feverfew for migraines.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a> The dried leaves--and sometimes flowers and stems--of feverfew are used to make supplements, including capsules, tablets, and liquid extracts.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a> Feverfew has been used for centuries for fevers, headaches, stomach aches, toothaches, insect bites, infertility, and problems with menstruation and labor during childbirth.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a> Feverfew has also been used for psoriasis, allergies, asthma, tinnitus (ringing or roaring sounds in the ears), dizziness, nausea, and vomiting.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a>

Some research suggests that feverfew may be helpful in preventing migraine headaches; however, results have been mixed and more evidence is needed from well-designed studies.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a> People who take feverfew for a long time and then stop taking it may have headaches, nervousness, difficulty sleeping, stiff muscles, and joint pain.<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank" [1]</a>

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<a name="hdng1"></a>Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a> Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a>

Groenewegen WA, Heptinstall S. Amounts of feverfew in commercial preparations of the herb.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a> Groenewegen WA, Knight DW, Heptinstall S. Compounds extracted from feverfew that have anti-secretory activity contain an alpha-methylene butyrolactone unit.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a>

Johnson ES, Kadam NP, Anderson D, Jenkinson PC, Dewdney RS, Blowers SD. Investigation of possible genetoxic effects of feverfew in migraine patients.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a> Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a>

Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium).<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a> Hayes NA, Foreman JC. The activity of compounds extracted from feverfew on histamine release from rat mast cells.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank" [2]</a> Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559" TARGET="_blank" [3]</a>

O'Neill LA, Barrett ML, Lewis GP. Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect.<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559" TARGET="_blank" [3]</a>

Smolinski AT, Pestka JJ. Modulation of proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb 1 (ginseng) and parthenolide (feverfew).<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559" TARGET="_blank" [3]</a>

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1. <a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank">Feverfew [NCCAM Herbs at a Glance]</a>
<a href="http://nccam.nih.gov/health/feverfew/" TARGET="_blank">http://nccam.nih.gov/health/feverfew/</a>

2. <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank">Feverfew--an ancient remedy for modern times?</a>
<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660" TARGET="_blank">http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1291660</a>

3. <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559" TARGET="_blank">Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver</a>
<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559" TARGET="_blank">http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1185559</a>

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