Accutane or Isotretinoin is used to treat severe (cystic) acne that has not responded to oral or topical anti-infectives. This includes anitibiotic therapies. Isotretinoin has been used to treat other skin disorders, including keratosis follicularis, pityriasis rubra pilaris, lamellar ichthyosis and leukoplakia. | Accutane or Isotretinoin is used to treat severe (cystic) acne that has not responded to oral or topical anti-infectives. This includes anitibiotic therapies. Isotretinoin has been used to treat other skin disorders, including keratosis follicularis, pityriasis rubra pilaris, lamellar ichthyosis and leukoplakia. |