Cranberry - Get the Facts on Herbal Supplements

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  • Contrary to prior opinion, urine acidification does not appear to be the way that cranberry prevents urinary tract infections.<a href="#hdng0">(More...)</a>



<a name="hdng0"></a>Contrary to prior opinion, urine acidification does not appear to be the way that cranberry prevents urinary tract infections. More research is needed in this area. <a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Bailey DT, Dalton C, Joseph Daugherty F, et al. Can a concentrated cranberry extract prevent recurrent urinary tract infections in women? A pilot study.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There are multiple studies of cranberry (juice or capsules) for the prevention of urinary tract infections in healthy women and nursing home residents. While no single study convincingly demonstrates the ability of cranberry to prevent UTIs, the sum total of favorable evidence combined with laboratory research tends to support this use. It is not clear what dose is best.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There is some human evidence supporting the use of cranberry juice and cranberry supplements to prevent urinary tract infection (UTI), although most available studies are of poor quality.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

There is a lack of well-designed human studies of cranberry for the treatment of urinary tract infections. Laboratory research suggests that cranberry may not be an effective treatment when used alone, although it may be helpful as an adjunct to other therapies such as antibiotics.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There is preliminary evidence that cranberry is not effective in preventing urinary tract infections in children with neurogenic bladder.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Linsenmeyer TA, Harrison B, Oakley A, et al. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Cranberry has been investigated for numerous other medicinal uses, and promising areas of investigation include prevention of H. pylori infection, which causes gastrointestinal ulcers and dental plaque.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Limited laboratory research has examined the antiviral and antifungal activity of cranberry. There is a lack of reliable human studies supporting the use of cranberry in this area.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Based on a small amount of laboratory research, cranberry has been proposed for cancer prevention.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There is not enough scientific evidence to recommend cranberry supplementation in children (beyond amounts found in a normal balanced diet).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There is preliminary evidence that cranberry is not effective in preventing urinary symptoms related to pelvic radiation therapy in patients with prostate cancer.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Campbell G, Pickles T, D'yachkova Y. A randomised trial of cranberry versus apple juice in the management of urinary symptoms during external beam radiation therapy for prostate cancer.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> One and a half ounces of frozen juice concentrate twice daily by mouth has been used, as well as 4 to 5 milliliters of cranberry tincture three times daily by mouth.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> For urinary tract infection prevention, the recommended doses range from 90 to 480 milliliters (3 to 16 ounces) of cranberry cocktail twice daily, or 15 to 30 milliliters of unsweetened 100% cranberry juice daily. 300 milliliters per day (10 ounces) of commercially available cranberry cocktail (Ocean Spray®) has been used in well-designed research. Other forms of cranberry used include capsules, concentrate, and tinctures.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Between one and six 300 to 400 milligram capsules of hard gelatin concentrated cranberry juice extract, twice daily by mouth, given with water one hour before meals or two hours after meals has been used.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Some cranberry tinctures may have high alcohol content and may lead to vomiting if used with the drug disulfiram (Antabuse®) or metronidazole (Flagyl®).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Cranberry has not been shown effective as a treatment for documented UTI. Although cranberry may be used as an adjunct therapy in some cases, given the proven efficacy of antibiotics, cranberry should not be considered a first line treatment.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

High doses of cranberry may cause stomach distress and diarrhea, or may increase the risk of kidney stones in people with a history of oxalate stones.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Based on preliminary research, it is not clear if drinking cranberry juice increases or decreases the risk of kidney stone formation.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Preliminary research suggests that cranberry juice may increase vitamin B12 absorption in patients taking drugs that reduce stomach acid (antacids), such as proton pump inhibitors like lansoprazole (Prevacid®). This effect may be due to the acidity of the juice rather than an active component of cranberry itself.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Cranberry juice theoretically may increase the effects of antibiotics in the urinary tract and increase the excretion of some drugs in the urine. Cranberry juice may increase absorption of vitamin B12 in patients using proton pump inhibitors such as esomeprazole (Nexium®).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

In theory, cranberry juice may increase the excretion of some herbs or supplements in the urine.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. In theory, due to its acidic pH, cranberry juice may counteract antacids.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Theoretically cranberry products may increase the risk of bleeding in people taking other herbs or supplements like garlic or danshen.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Although controversial, some studies have shown that taking the prescription blood thinner warfarin (Coumadin®) and cranberry products at the same time can elevate the INR, which could increase the risk of bleeding.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Notably, many studies have been sponsored by the cranberry product manufacturer Ocean Spray®. Additional research is needed in this area before a strong recommendation can be made.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Because of its activity against some bacteria, cranberry juice has been proposed as helpful for mouth care. Many commercial cranberry juice products are high in sugar and may not be suitable for this purpose. There is not enough research in this area to make a clear recommendation.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Based on early research, cranberry may reduce the ability of Helicobacter pylori bacteria to live in the stomach and cause ulcers. Further research is needed to confirm these results.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Inhibition of H. pylori bacteria, which may lead to gastrointestinal ulcers, may be increased when oregano and cranberry are taken together.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Cranberry seems to work by preventing bacteria from sticking to cells that line the bladder.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Waites KB, Canupp KC, Armstrong S, et al. Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Alzheimer's herbs and supplements, antacids, anthelminthics (expel worms), antibacterials, antifungals, cholesterol-lowering herbs and supplements, antineoplastics, antioxidants, antiparasitics, antivirals, herbs and supplements broken down by the liver, diuretics, lingonberry, salicylate-containing herbs like willow bark, urine-acidifying herbs and supplements, and vitamin B12 may interact with cranberry.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Alzheimer's drugs, anthelmintics (expel worms), antifungals, cholesterol-lowering drugs, antineoplastics (anticancer agents), antiprotozoals, antiviral agents, clarithromycin, drugs broken down by the liver, diuretics, salicylates like aspirin, and drugs eliminated by the kidneys may interact with cranberry.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Cranberry should be avoided by people with an allergy/hypersensitivity to Vaccinium species (cranberries and blueberries).<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Chambers BK, Camire ME. Can cranberry supplementation benefit adults with type 2 diabetes? Diabetes Care 2003 Sep;26(9):2695-6.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

On average, six ounces of cranberry juice contains approximately 100 calories. One study showed the possibility for occurrence of vaginal yeast infections in those women who often consume cranberry juice, although this has not been proven. Use cautiously if taking anticoagulants (blood thinners) such as warfarin, medications that affect the liver, or aspirin.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> One study suggests that 500 milliliters of cranberry juice with 1,500 milliliters of water was sufficient in helping prevent the formation of oxalate kidney stones.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Gettman MT, Ogan K, Brinkley LJ, et al. Effect of cranberry juice consumption on urinary stone risk factors.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Shmuely H, Yahav J, Samra Z, et al. Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Zhang L, Ma J, Pan K, et al. Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Preliminary study results show that cranberry juice may increase overall ability to remember. Further well-designed clinical trials are needed to confirm these results.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Crews WD Jr, Harrison DW, Griffin ML, et al. A double-blinded, placebo-controlled, randomized trial of the neuropsychologic efficacy of cranberry juice in a sample of cognitively intact older adults: pilot study findings.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Kontiokari T, Salo J, Eerola E, et al. Cranberry juice and bacterial colonization in children--a placebo-controlled randomized trial.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Cranberry juice is reported to decrease urine levels of calcium, increase levels of urine magnesium and potassium, and increase urine levels of oxalate.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> There is preliminary evidence that cranberry juice may reduce urine odor from incontinence or bladder catheterization.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> It is proposed that skin irritation at urostomy sites may be related to urine pH. Cranberry juice can lower urine pH and has been tested for this purpose.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> In large quantities, cranberry juice may lower urine pH, making it more acidic.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

There are no clear dosing guidelines, but given the safety of cranberry, it may be reasonable to recommend the use of moderate amounts of cranberry juice cocktail to prevent UTI in non-chronically ill individuals.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a> Safety has not been determined in pregnancy and breastfeeding, although cranberry juice is believed to be safe in amounts commonly found in foods.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

Patients with diabetes or glucose intolerance may want to drink sugar-free cranberry juice to avoid a high sugar intake.<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank" [1]</a>

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Section Contents:
  • Historically, cranberry fruits and leaves were used for a variety of problems, such as wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.<a href="#hdng1">(More...)</a>

  • Hiking: Cranberry Lake Campground offers a great base for hiking the numerous trails in the area.<a href="#hdng2">(More...)</a>

  • November 9, 1959: Cranberry Crisis - Three weeks before Thanksgiving, the FDA announces that chemists had discovered aminotriazole, a recognized carcinogen, in that year's cranberry crop. Cranberries cleared for sale during the crisis were the only FDA product ever to boast correctly of being tested and cleared "by FDA."<a href="#hdng3">(More...)</a>



<a name="hdng1"></a>Historically, cranberry fruits and leaves were used for a variety of problems, such as wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems. <a href="http://nccam.nih.gov/health/cranberry/" TARGET="_blank" [2]</a> Recently, cranberry products have been used in the hope of preventing or treating urinary tract infections or Helicobacter pylori infections that can lead to stomach ulcers, or to prevent dental plaque.<a href="http://nccam.nih.gov/health/cranberry/" TARGET="_blank" [2]</a>

Eating cranberry products in food appears to be safe, but drinking excessive amounts of juice could cause gastrointestinal upset or diarrhea. People who think they have a urinary tract infection should see a health care provider for proper diagnosis and treatment.<a href="http://nccam.nih.gov/health/cranberry/" TARGET="_blank" [2]</a>

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<a name="hdng2"></a>Hiking: Cranberry Lake Campground offers a great base for hiking the numerous trails in the area. <a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a> Make a reservation for this campground with ReserveAmerica. One of the largest remote lakes in the Adirondacks and it's proximity to 50,000 acres of wilderness, intermingled with 50 miles of well developed trails makes Cranberry Lake the outdoor enthusiasts perfect vacation spot. Whether it's fishing, boating or just laying back and enjoying your well deserved vacation, Cranberry Lake is the spot for you.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a> From Cranberry Lake to other Adirondack Campgrounds requires only a short trip on a major highway.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a> Cranberry Lake Campground has developed through several phases of construction.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a> Take Route 3 to Cranberry Lake Village, turn left on Lone Pine Road, campground is 1 mile south.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a>

Historic Interest: The Cranberry Lake area is one of the largest remote areas remaining in the state.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a> Amenities: 173 campsites; hot showers; flush toilets; trailer dump station; recycling center; boat launch near Cranberry Lake hamlet; pay telephone; sand beach with bathhouse; Picnic area with tables, fireplaces, and grills; Amphitheater; pavilion rental; handicapped accessible camping sites, picnic area, fishing pier.<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank" [3]</a>

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<a name="hdng3"></a>November 9, 1959: Cranberry Crisis - Three weeks before Thanksgiving, the FDA announces that chemists had discovered aminotriazole, a recognized carcinogen, in that year's cranberry crop. Cranberries cleared for sale during the crisis were the only FDA product ever to boast correctly of being tested and cleared "by FDA." <a href="http://www.fda.gov/centennial/this_week/45_nov_05_nov_11.html" TARGET="_blank" [4]</a> The cranberry contamination was first reported in the Pacific Northwest, but soon after, cranberries grown in other states were implicated as well.<a href="http://www.fda.gov/centennial/this_week/45_nov_05_nov_11.html" TARGET="_blank" [4]</a>

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1. <a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank">MedlinePlus Herbs and Supplements: Cranberry (Vaccinium macrocarpon)</a>
<a href="http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html" TARGET="_blank">http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-cranberry.html</a>

2. <a href="http://nccam.nih.gov/health/cranberry/" TARGET="_blank">Cranberry [NCCAM Herbs at a Glance]</a>
<a href="http://nccam.nih.gov/health/cranberry/" TARGET="_blank">http://nccam.nih.gov/health/cranberry/</a>

3. <a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank">Cranberry Lake - NYS Dept. of Environmental Conservation</a>
<a href="http://www.dec.ny.gov/outdoor/24460.html" TARGET="_blank">http://www.dec.ny.gov/outdoor/24460.html</a>

4. <a href="http://www.fda.gov/centennial/this_week/45_nov_05_nov_11.html" TARGET="_blank">This Week In FDA History</a>
<a href="http://www.fda.gov/centennial/this_week/45_nov_05_nov_11.html" TARGET="_blank">http://www.fda.gov/centennial/this_week/45_nov_05_nov_11.html</a>

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